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Jim Dimitroulakos Selected Research

Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)

11/2014Monensin inhibits epidermal growth factor receptor trafficking and activation: synergistic cytotoxicity in combination with EGFR inhibitors.
10/2008Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status.
7/2006Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway.
7/2002Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas.

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Jim Dimitroulakos Research Topics

Disease

23Neoplasms (Cancer)
11/2018 - 07/2002
10Squamous Cell Carcinoma of Head and Neck
12/2018 - 07/2002
8Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2018 - 07/2002
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2016 - 03/2005
5Breast Neoplasms (Breast Cancer)
08/2018 - 02/2009
5Carcinoma (Carcinomatosis)
01/2014 - 07/2002
4Triple Negative Breast Neoplasms
08/2020 - 12/2016
3Ovarian Neoplasms (Ovarian Cancer)
08/2020 - 02/2009
2Lung Neoplasms (Lung Cancer)
02/2019 - 01/2016
2Carcinogenesis
01/2018 - 01/2018
1Hypoxia (Hypoxemia)
08/2020
1Tuberous Sclerosis (Bourneville's Disease)
02/2019
1Lymphangioleiomyomatosis (Lymphangiomyomatosis)
02/2019
1Lung Diseases (Lung Disease)
02/2019
1Oropharyngeal Neoplasms
01/2019
1Pulmonary Arterial Hypertension
11/2016
1Septic Shock (Toxic Shock Syndrome)
11/2016
1Coronary Artery Disease (Coronary Atherosclerosis)
11/2016
1Acute Coronary Syndrome
11/2016
1Prostatic Neoplasms (Prostate Cancer)
01/2013
1Vesicular Stomatitis
08/2012
1Colorectal Neoplasms (Colorectal Cancer)
02/2012
1Neoplasm Metastasis (Metastasis)
02/2012
1Neuroblastoma
12/2010
1Embryonal Carcinoma
12/2010
1Mesothelioma
09/2010
1Malignant Mesothelioma
09/2010
1Glioblastoma (Glioblastoma Multiforme)
10/2008

Drug/Important Bio-Agent (IBA)

11Lovastatin (Mevacor)FDA LinkGeneric
01/2014 - 07/2002
6Cisplatin (Platino)FDA LinkGeneric
08/2020 - 07/2010
5Gefitinib (Iressa)FDA Link
08/2020 - 03/2005
5Erlotinib Hydrochloride (CP 358,774)FDA Link
03/2016 - 07/2006
4Proteins (Proteins, Gene)FDA Link
01/2018 - 02/2009
4ErbB Receptors (EGF Receptor)IBA
01/2016 - 11/2003
4Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA
11/2014 - 07/2002
3Metformin (Glucophage)FDA LinkGeneric
08/2020 - 01/2012
3Pharmaceutical PreparationsIBA
02/2019 - 07/2006
3Biomarkers (Surrogate Marker)IBA
11/2018 - 11/2015
3Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
01/2018 - 10/2008
3Mevalonic Acid (Mevalonate)IBA
01/2014 - 07/2002
3Messenger RNA (mRNA)IBA
01/2014 - 09/2010
2Phosphotransferases (Kinase)IBA
02/2019 - 10/2008
2Mechanistic Target of Rapamycin Complex 1IBA
02/2019 - 01/2018
2Transcription Factors (Transcription Factor)IBA
08/2018 - 10/2007
2Activating Transcription Factor 3IBA
08/2018 - 01/2016
2DNA (Deoxyribonucleic Acid)IBA
08/2017 - 01/2017
2RNA (Ribonucleic Acid)IBA
11/2016 - 01/2016
2Rosuvastatin Calcium (Crestor)FDA Link
03/2016 - 07/2006
2MicroRNAs (MicroRNA)IBA
01/2013 - 02/2012
2Histone Deacetylase InhibitorsIBA
08/2011 - 09/2010
2VorinostatFDA Link
08/2011 - 09/2010
2PlatinumIBA
08/2011 - 02/2009
2Tyrosine Kinase InhibitorsIBA
03/2005 - 11/2003
1TOR Serine-Threonine KinasesIBA
02/2019
1HydrogelsIBA
02/2019
1lipoarabinomannan (LAM)IBA
02/2019
1C-Reactive ProteinIBA
01/2019
1AnthracyclinesIBA
08/2018
1Doxorubicin (Adriamycin)FDA LinkGeneric
08/2018
1TamoxifenFDA LinkGeneric
01/2018
1ICG 001IBA
01/2018
1CateninsIBA
01/2018
1Sirolimus (Rapamycin)FDA Link
01/2018
1Phenobarbital (Luminal)FDA Link
01/2018
1Valproic Acid (Depakote)FDA LinkGeneric
01/2018
1Simvastatin (Zocor)FDA LinkGeneric
01/2018
1Viral Oncogene ProteinsIBA
10/2017
1Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA
08/2017
1Progesterone Receptors (Progesterone Receptor)IBA
12/2016
1Histone Deacetylases (Histone Deacetylase)IBA
12/2016
1Estrogen Receptor alphaIBA
12/2016
1Long Noncoding RNAIBA
11/2016
1Focal Adhesion Protein-Tyrosine KinasesIBA
01/2016
1AldosteroneIBA
11/2015
1Cyclin-Dependent Kinase 6IBA
11/2015
1cediranib (AZD2171)IBA
11/2015
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
11/2015
1Anti-Bacterial Agents (Antibiotics)IBA
11/2014
1Monensin (Coban)IBA
11/2014
1InterferonsIBA
08/2012
1ParaffinIBA
02/2012
1BRCA1 ProteinIBA
08/2011
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
12/2010
1GAP-43 Protein (GAP 43 Protein)IBA
12/2010
1Differentiation AntigensIBA
12/2010
1BucladesineIBA
12/2010
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
09/2010
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2010
1LigandsIBA
09/2010
1Small Interfering RNA (siRNA)IBA
07/2010
1Carboplatin (JM8)FDA LinkGeneric
07/2010
1epidermal growth factor receptor VIIIIBA
10/2008
1Adenosine Triphosphate (ATP)IBA
03/2005

Therapy/Procedure

7Therapeutics
08/2020 - 11/2003
3Drug Therapy (Chemotherapy)
08/2018 - 08/2011
1Aftercare (After-Treatment)
01/2018
1Transplantation
01/2018
1Immunotherapy
10/2017
1Combination Drug Therapy (Combination Chemotherapy)
01/2016
1Oncolytic Virotherapy
08/2012